Too Little Feel Good

Endorphin, Enkephalon, and Endocannabinoid Deficiency And What You Can Do About It Yes you can dampen a pain signal, numb the nerve with lidocaine, and zone it out. But then the nerve is just numb, it's supposed to function. What if the problem isn't too much pain, just too little relief? What is there is something wrong with your feel good signaling system? What if it is under active? You may need replacement therapy not a pain killer. Just what is our pain/ pleasure system

NMDA Receptor: The Drugs

NMDA receptor antagonist drugs definitely have a place in controlling chronic pain. But my goodness, we haven't found the right one yet! Maybe a combination of supplements and one of the drugs listed below can help you out. All target decreasing brain inflammation by calming down your microglia, decreasing NMDA signaling, and/or blocking glutamate release. Any damage to brain cells, inflammation, infection, trauma, causes the neurons to release glutamate. So I will include

Blocking the Signal in Central Sensitivity Pain - The NMDA Receptor

We've talked about this receptor before, but it is such a powerful creator of pain, it deserves a post of it's own. If it is stimulated, you hurt. Glutamate tells the receptor to open up, calcium rushes in, and voila, a whole slew of "excitotoxins" flood the nerve and gives you pain. Now, pain certainly has it's place. We need to pull our finger out of the flame. But here we are talking about inappropriate hyper-intense pain signaling. Too much NMDA receptor activity leads

Treating Central Sensitivity Syndromes

Fix Your Blood Brain Barrier Then Soothe and Nourish Your Microglia The famous blood brain barrier Here's the unifying concept here. Right back down to the basics, the cells in your brain which have become degenerated, unbalanced and inflamed. Which cells are they? They are the microglia, the immune cell guardians of the brain. Why did they get inflamed? Because you have a "leaky brain" or, more exactly. a "leaky blood brain barrier". We used to think the brain was all abo

Central Sensitivity Syndromes:

SOME CLUES, SOME ANSWERS Have you forgotten? I'm talking about the pains doctors can't see. Fibromyalgia, TMJ, Irritable Bowel Syndrome, and more. The problem appears to be in the nerve/brain signals, not in the part that hurts you. Signal intensity is off. Neuronal transmission needs fixing. The Clues: Lets go back to the gene variants involved in susceptible individuals. Serotonin Transmitter, Adrenergic Response Element, COMT. First of all, these genes have NOTHING to do

Pains Doctors Can't See

Yes, we doctors tend to do well with those aches and pains we can see. There, on X-ray says the chiropractor, on ultrasound says the ObGyn, on MRI says the orthopod, in this blood work says the rheumatologist. Set the broken bone, take out the cyst, replace the knee, go on a drug. But what about all those things we can't see or measure with a specific blood test? What can we do for those? For lack of a better term, I will call these functional pains and believe me they